Research

Peer Reviewed Scientific Publications

  1. Frégeau G, Sarduy R, Elimam H, Esposito CL, Mellal K, Ménard L, Leitão da Graça SD, Proulx C, Zhang J, Febbraio M, Soto Y, Lubell WD, Ong H, Marleau S.  Atheroprotective and atheroregressive potential of azapeptide derivatives of GHRP-6 as selective CD36 ligands in apolipoprotein E-deficient mice.  Atherosclerosis.  2020  Aug;307:52-62.  PMID: 32721647.
  2. Soto Y, Mangat R, Kelly S, Vazquez AM, Proctor SD.  Anti-Glycosaminoglycan Monoclonal Antibody Prevents Cardiac Hypertrophy in a Rat Model of Metabolic Syndrome.  Atherosclerosis.  2019 Aug;287:E75.  DOI:  10.1016/j.atherosclerosis.2019.06.213.
  3. Soto Y, Mangat R, Kelly S, Vazquez AM, Proctor SD.  Novel Anti-proteoglycan Antibody Inhibits Arterial Lipoprotein Retention and Prevents Cardiac Hyperthrophy in a Rat Model of Insulin Resistance.  Atherosclerosis Supplements.  2018 June;32:27.   DOI:  10.1016/j.atherosclerosissup.2018.04.078.
  4. Brito V, Mellal K, Zoccal KF, Soto Y, Menard L, Sarduy R, Faccioli LH, Ong H, Vázquez AM, Marleau S.  Atheroregressive Potential of the Treatment with a Chimeric Monoclonal Antibody against Sulfated Glycosaminoglycans on Pre-existing Lesions in Apolipoprotein E-Deficient Mice.  Frontiers in Pharmacology.  2017 Nov.  DOI:  10.3389/fphar.2017.00782.
  5. Sarduy R, Brito V, Castillo A, Soto Y, Griñán T, Marleau S, Vázquez AM.   Dose-Dependent Induction of an Idiotypic Cascade by Anti-Glycosaminoglycan Monoclonal Antibody in apoE -/- Mice: Association with Atheroprotection.  Front Immunol.  2017 Mar 3;8:232.  PMID  28316603.
  6. Mangat R, Soto Y, Vázquez AM, Proctor SD.  A Novel Anti-Proteoglycan Antibody Inhibits Arterial Retention of Remnant Lipoproteins in a Rat Model of Insulin Resistance.   The Canadian Journal of Cardiology.  2016 Oct;32(10):578.  DOI:  10.1016/j.cjca.2016.07.101.
  7. Delgado-Roche L, Brito V, Acosta E, Pérez A, Fernández JR, Hernández-Matos Y, Griñán T, Soto Y, León OS, Marleau S, Vázquez AM.  Arresting progressive atherosclerosis by immunization with an anti-glycosaminoglycan monoclonal antibody in apolipoprotein E-deficient mice.  Free Radic Biol Med. 2015 Dec;89:557-66.  PMID:  26454078. 
  8. Soto Y, Mesa N, Alfonso Y, Pérez A, Batlle F, Griñán T, Pino A, Viera J, Frómeta M, Brito V, Olivera A, Zayas F, Vázquez AM.  Targeting arterial wall sulfated glycosaminoglycans in rabbit atherosclerosis with a mouse/human chimeric antibody.  MAbs.  2014 6(5):1340-6.  PMID:  25517318.
  9. Brito V, Mellal K, Zoccal KF, Soto Y, Ménard L, Sarduy R, Faccioli LH, Ong H, Vázquez AM, Marleau S.  Atheroregressive Potential of the Treatment with a Chimeric Monoclonal Antibody against Sulfated Glycosaminoglycans on Pre-existing Lesions in Apolipoprotein E-Deficient Mice.  Front Pharmacol.  2017 Nov 1;8:782.   PMID:  29163168.